Mdm2tm3.1Glo
Targeted Allele Detail
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| Symbol: |
Mdm2tm3.1Glo |
| Name: |
transformed mouse 3T3 cell double minute 2; targeted mutation 3.1, Guillermina Lozano |
| MGI ID: |
MGI:4835494 |
| Synonyms: |
Mdm2SNP309G |
| Gene: |
Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
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| Alliance: |
Mdm2tm3.1Glo page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:164201
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Intron 1 was replaced with the corresponding human intron 1 with a G in position 309. A floxed neo cassette was also inserted into intron 3 and then removed via Cre mediated recombination. RT-PCR analysis indicated higher levels of RNA expression in spleens and thymi from homozygous mice relative to wild-type mice.
(J:164201)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mdm2 Mutation: |
54 strains or lines available
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| Original: |
J:164201 Post SM, et al., A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell. 2010 Sep 14;18(3):220-30 |
| All: |
3 reference(s) |
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Analysis Tools
